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The determination method of l-Ephedrine and dl-Methylephedrine by gas chromatography was developed, using reactive alkaline precolumn packed with celite 545 containing KOH. Symmetrical peaks were achieved under the condition, inlet temperature, 180oC-230oC; column temperature, 130oC-160oC; carrier gas flow rate, 30ml/minute. The peaks of the salts coincided with those of bases. When this method was applied to preparations, using d-dimethylaminobenzaldehyde as inner standard, good results were obtained. The relative retention times of l-Ephedrine and dl-Methylephedrine to p-dimethyl aminobenzaldehyde were 0.50 and 0.65 respectively.
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